• Target：
• UPAR

• Fields：
• >>Complement and coagulation cascades;>>Proteoglycans in cancer

• Gene Name：
• PLAUR MO3 UPAR

• Protein Name：
• U-PAR

• Human Gene Id：
• 5329

• Human Swiss Prot No：
• Q03405

• Mouse Gene Id：
• 18793

• Mouse Swiss Prot No：
• P35456

• Rat Gene Id：
• 50692

• Rat Swiss Prot No：
• P49616

• Immunogen：
• Synthesized peptide derived from human U-PAR

• Specificity：
• This antibody detects endogenous levels of Human U-PAR

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:1000-2000 ELISA 1:5000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Urokinase plasminogen activator surface receptor (U-PAR;uPAR;Monocyte activation antigen Mo3;CD antigen CD87)

• Molecular Weight(Da)：
• 37kD

• Background：
• function:Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.,similarity:Contains 3 UPAR/Ly6 domains.,subunit:Monomer (Probable). Interacts with MRC2.,

• Function：
• protein amino acid lipidation, GPI anchor metabolic process, GPI anchor biosynthetic process, phospholipid metabolic process, glycerophospholipid metabolic process, cell motion, chemotaxis, blood coagulation, hemostasis, behavior,locomotory behavior, lipid biosynthetic process, phospholipid biosynthetic process, response to wounding, attachment of GPI anchor to protein, organophosphate metabolic process, regulation of proteolysis, phosphoinositide metabolic process, regeneration, growth, wound healing, lipoprotein metabolic process, lipoprotein biosynthetic process, tissue regeneration, taxis, skeletal muscle regeneration, glycerolipid biosynthetic process, glycerophospholipid biosynthetic process, glycerolipid metabolic process, phosphoinositide biosynthetic process, developmental growth, coagulation,regulation of body fluid levels,

• Subcellular Location：
• Cell membrane . Cell projection, invadopodium membrane . Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. .; [Isoform 1]: Cell membrane ; Lipid-anchor, GPI-anchor .; [Isoform 2]: Secreted .

• Expression：
• Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

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