• Target：
• SENP2

• Fields：
• >>Nucleocytoplasmic transport;>>Wnt signaling pathway

• Gene Name：
• SENP2

• Protein Name：
• Sentrin-specific protease 2

• Human Gene Id：
• 59343

• Human Swiss Prot No：
• Q9HC62

• Mouse Gene Id：
• 75826

• Mouse Swiss Prot No：
• Q91ZX6

• Rat Gene Id：
• 78973

• Rat Swiss Prot No：
• Q9EQE1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SENP2. AA range:481-530

• Specificity：
• SENP2 Polyclonal Antibody detects endogenous levels of SENP2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SENP2;KIAA1331;Sentrin-specific protease 2;Axam2;SMT3-specific isopeptidase 2;Smt3ip2;Sentrin/SUMO-specific protease SENP2

• Observed Band(KD)：
• 68kD

• Background：
• SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004],

• Function：
• domain:The N-terminus is necessary and sufficient for nuclear envelope targeting.,function:Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.,PTM:Polyubiquitinated; which leads to proteasomal degradation.,similarity:Belongs to the peptidase C48 family.,subcellular location:Shuttles between cytoplasm and nucleus.,subunit:Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus.,

• Subcellular Location：
• Nucleus, nuclear pore complex . Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side . Cytoplasm . Shuttles between cytoplasm and nucleus. .

• Expression：
• Brain,Fetal brain,Melanoma,Teratocarcinoma,

The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKα J Biol Chem. 2022 Feb;298(2):. WB Human,Mouse liver

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