• Target：
• QIK/QSK

• Fields：
• >>Glucagon signaling pathway

• Gene Name：
• SIK2 KIAA0781 QIK SNF1LK2

• Protein Name：
• QIK/QSK (Phospho-Thr175/163)

• Human Gene Id：
• 23235

• Human Swiss Prot No：
• Q9H0K1

• Mouse Gene Id：
• 235344

• Mouse Swiss Prot No：
• Q8CFH6

• Immunogen：
• Synthesized peptide derived from human QIK/QSK (Phospho-Thr175/163)

• Specificity：
• This antibody detects endogenous levels of QIK/QSK (Phospho-Thr175/163) at Human, Mouse,Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)

• Observed Band(KD)：
• 105kD

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subunit:Interacts with and phosphorylates TORC2/CRTC2.,

• Subcellular Location：
• Cytoplasm . Endoplasmic reticulum membrane .

• Expression：
• Brain,Colon,Lung,Testis,

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