SRC-1 (Phospho Thr1179) rabbit pAb

  • Catalog No.：YP1597
  • Applications：WB;ELISA
  • Reactivity：Human;Mouse
    • Target：
    • SRC-1
    • Fields：
    • >>Estrogen signaling pathway;>>Thyroid hormone signaling pathway;>>Pathways in cancer;>>Breast cancer
    • Gene Name：
    • NCOA1 BHLHE74 SRC1
    • Protein Name：
    • SRC-1 (Phospho Thr1179)
    • Human Gene Id：
    • 8648
    • Human Swiss Prot No：
    • Q15788
    • Mouse Swiss Prot No：
    • P70365
    • Immunogen：
    • Synthesized peptide derived from human SRC-1 (Phospho Thr1179)
    • Specificity：
    • This antibody detects endogenous levels of Human,Mouse SRC-1 (Phospho Thr1179)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Nuclear receptor coactivator 1 (NCoA-1;EC 2.3.1.48;Class E basic helix-loop-helix protein 74;bHLHe74;Protein Hin-2;RIP160;Renal carcinoma antigen NY-REN-52;Steroid receptor coactivator 1;SRC-1)
    • Observed Band(KD)：
    • 158kD
    • Background：
    • The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
    • Function：
    • catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,disease:A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.,domain:Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro.,domain:The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity.,function:Nuclear receptor coactivator that directly binds nuclear receptors and stimulates t
    • Subcellular Location：
    • Nucleus .
    • Expression：
    • Widely expressed.

    Attributes

    • Code：
    • YP1597
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-07-24
    Order

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