• Target：
• c-JUN

• Fields：
• >>Endocrine resistance;>>MAPK signaling pathway;>>ErbB signaling pathway;>>cAMP signaling pathway;>>Mitophagy - animal;>>Apoptosis;>>Wnt signaling pathway;>>Osteoclast differentiation;>>Focal adhesion;>>Tight junction;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>C-type lectin receptor signaling pathway;>>IL-17 signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>TNF signaling pathway;>>Neurotrophin signaling pathway;>>GnRH signaling pathway;>>Estrogen signaling pathway;>>Oxytocin signaling pathway;>>Relaxin signaling pathway;>>Non-alcoholic fatty liver disease;>>AGE-RAGE signaling pathway in diabetic complications;>>Cocaine addiction;>>Amphetamine addiction;>>Epithelial cell signaling in Helicobacter pylori infection;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Yersinia infection;>>Leishmaniasis;>>Chagas di

• Gene Name：
• JUN

• Protein Name：
• C-Jun (Hydroxylated-p244); Transcription factor AP-1;jun;c-jun；AP-1

• Human Gene Id：
• 3725

• Human Swiss Prot No：
• P05412

• Mouse Gene Id：
• 16476

• Mouse Swiss Prot No：
• P05627

• Rat Gene Id：
• 24516

• Rat Swiss Prot No：
• P17325

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Transcription factor AP-1 (Activator protein 1;AP1;Proto-oncogene c-Jun;V-jun avian sarcoma virus 17 oncogene homolog;p39)

• Molecular Weight(Da)：
• 36kD

• Observed Band(KD)：
• 43kD

• Background：
• function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.,

• Function：
• protein import into nucleus, translocation, response to reactive oxygen species, angiogenesis, blood vessel development, release of cytochrome c from mitochondria, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, vasculature development, response to molecule of bacterial origin,regulation of myeloid leukocyte differentiation, positive regulation of myeloid leukocyte differentiation, regulation of DNA replication, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein targeting, protein import into nucleus, cellular ion homeostasis, intracellular protein transport, nucleocytoplasmic transport, apoptosis, response to oxidative stress, mitochondrion organization, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway

• Subcellular Location：
• Nucleus

• Expression：
• Expressed in the developing and adult prostate and prostate cancer cells.

PSME3 Promotes TGFB1 Secretion by Pancreatic Cancer Cells to Induce Pancreatic Stellate Cell Proliferation. Journal of Cancer J Cancer. 2019; 10(9): 2128–2138 WB Human 1:1000 Panc-1 cell, Bxpc-3 cell

AP-1 confers resistance to anti-cancer therapy by activating XIAP. Oncotarget Oncotarget. 2018 Mar 6; 9(18): 14124–14137 WB Human MCF7 cell

Zhang, Kai-liang, et al. "Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas." Cancer letters 342.1 (2014): 139-149.

Alpha-Momorcharin Inhibits Proinflammatory Cytokine Expression by M1 Macrophages but Not Anti-Inflammatory Cytokine Expression by M2 Macrophages Journal of Inflammation Research Fubing Shen WB Human

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