TCL1 (PT0225R) rabbit mAb

  • Catalog No.：YM7215
  • Applications：IHC; WB;; ELISA
  • Reactivity：Human;
    • Target：
    • TCL1
    • Fields：
    • >>PI3K-Akt signaling pathway
    • Gene Name：
    • TCL1A
    • Protein Name：
    • TCL1
    • Human Gene Id：
    • 8115
    • Human Swiss Prot No：
    • P56279
    • Immunogen：
    • Synthesized peptide derived from human TCL1 AA range:50-114
    • Specificity：
    • This antibody detects endogenous levels of TCL1
    • Formulation：
    • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    • Source：
    • Monoclonal, Rabbit IgG1, Kappa
    • Dilution：
    • IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
    • Purification：
    • Recombinant Expression and Affinity purified
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Anti TCL1A;Lymphoma/leukemia, T-cell;Oncogene TCL-1;Oncogene TCL1;P14 TCL1;P14 TCL1 protein;Protein p14 TCL1;T cell leukemia 1;T cell lymphoma 1;T cell lymphoma 1A;T-cell leukemia/lymphoma 1A;T-cell leukemia/lymphoma protein 1A;TCL 1 protein;TCL1;TCL1 oncogene;TCL1 PEN;Tcl1a;TCL1A;TCL1A_HUMAN
    • Molecular Weight(Da)：
    • 13kD
    • Background：
    • Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],
    • Function：
    • disease:Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta locuses.,function:Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.,similarity:Belongs to the TCL1 family.,subcellular location:Microsomal fraction.,subunit:Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.,tissue specificity:Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.,
    • Subcellular Location：
    • Cytoplasmic, Nuclear
    • Expression：
    • Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.

    Attributes

    • Code：
    • YM7215
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-07-24
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