TGF β Receptor I (ABT-TGFR1) mouse mAb

    • Catalog No.:YM6100
    • Applications:IHC;IF;ELISA
    • Reactivity:Human;Mouse;Rat;Bovin;
      • Target:
      • TGF β Receptor I
      • Fields:
      • >>MAPK signaling pathway;>>Cytokine-cytokine receptor interaction;>>FoxO signaling pathway;>>Endocytosis;>>Cellular senescence;>>TGF-beta signaling pathway;>>Apelin signaling pathway;>>Osteoclast differentiation;>>Hippo signaling pathway;>>Adherens junction;>>Th17 cell differentiation;>>Relaxin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Chagas disease;>>Hepatitis B;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Colorectal cancer;>>Pancreatic cancer;>>Chronic myeloid leukemia;>>Hepatocellular carcinoma;>>Gastric cancer;>>Diabetic cardiomyopathy
      • Gene Name:
      • TGFBR1 ALK5 SKR4
      • Protein Name:
      • TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4)
      • Human Gene Id:
      • 7046
      • Human Swiss Prot No:
      • P36897
      • Immunogen:
      • Synthesized peptide derived from human TGF β Receptor I AA range: 34-100
      • Specificity:
      • This antibody detects endogenous levels of TGF β Receptor I protein.
      • Formulation:
      • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
      • Source:
      • Mouse, Monoclonal/IgG2a, kappa
      • Dilution:
      • IHC 1:50-200. IF 1:50-200. ELISA 1:500-5000
      • Purification:
      • The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Molecular Weight(Da):
      • 55kD
      • Observed Band(KD):
      • 55kD
      • Background:
      • The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
      • Function:
      • catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in TGFBR1 are the cause of aortic aneurysm familial thoracic type 5 (AAT5) [MIM:608967]. Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,disease:Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A) [MIM:609192]; also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS). LDS1 is an aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by arterial tort
      • Subcellular Location:
      • Membranous
      • Expression:
      • Found in all tissues examined, most abundant in placenta and least abundant in brain and heart. Expressed in a variety of cancer cell lines (PubMed:25893292).
      • Products Images
      • Human colon tissue was stained with Anti-TGF β Receptor I (ABT-TGFR1) Antibody
      • Human colon carcinoma tissue was stained with Anti-TGF β Receptor I (ABT-TGFR1) Antibody
      • Human colon carcinoma tissue was stained with Anti-TGF β Receptor I (ABT-TGFR1) Antibody
      • Human pancreas tissue was stained with Anti-TGF β Receptor I (ABT-TGFR1) Antibody
      • Human stomach tissue was stained with Anti-TGF β Receptor I (ABT-TGFR1) Antibody
      • Immunohistochemical analysis of paraffin-embedded Colon. 1, Antibody was diluted at 1:200(4° overnight). 2, Citric acid ,pH6.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).