Pax-8 Monoclonal Antibody (4H15)

    • Catalog No.：YM0509
    • Applications：WB;ELISA
    • Reactivity：Human
      • Target：
      • Pax-8
      • Fields：
      • >>Thyroid hormone synthesis;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Thyroid cancer
      • Gene Name：
      • PAX8
      • Protein Name：
      • Paired box protein Pax-8
      • Human Gene Id：
      • 7846
      • Human Swiss Prot No：
      • Q06710
      • Mouse Swiss Prot No：
      • Q00288
      • Immunogen：
      • Purified recombinant fragment of human Pax-8 expressed in E. Coli.
      • Specificity：
      • Pax-8 Monoclonal Antibody detects endogenous levels of Pax-8 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • PAX8;Paired box protein Pax-8
      • Molecular Weight(Da)：
      • 48kD
      • References：
      • 1. Thyroid. 2009 Jan;19(1):61-8.
        2. Cancer Genet Cytogenet. 2010 Jan 1;196(1):7-13.
        3. Cancer Cytopathol. 2010 Oct 25;118(5):298-302.
      • Background：
      • This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],
      • Function：
      • caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,developmental stage:In developing excretory system, during thyroid differentiation and in adult thyroid.,disease:Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.,function:Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cell
      • Subcellular Location：
      • Nucleus.
      • Expression：
      • Expressed in the excretory system, thyroid gland and Wilms tumors.
      • Products Images
      • Western Blot analysis using Pax-8 Monoclonal Antibody against HeLa (1),HEK293 (2) and Raji (3) cell lysate.

      Attributes

      • Code：
      • YM0509
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-11-30
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