PAR1 (Cleaved-Ser42) Polyclonal Antibody

    • Catalog No.:YT6162
    • Applications:WB;ELISA
    • Reactivity:Human;Mouse;Rat
      • Target:
      • PAR1
      • Fields:
      • >>Rap1 signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>Complement and coagulation cascades;>>Platelet activation;>>Regulation of actin cytoskeleton;>>Pathogenic Escherichia coli infection;>>Pathways in cancer
      • Gene Name:
      • F2R CF2R PAR1 TR
      • Protein Name:
      • Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
      • Human Gene Id:
      • 2149
      • Human Swiss Prot No:
      • P25116
      • Mouse Swiss Prot No:
      • P30558
      • Immunogen:
      • Synthesized peptide derived from human PAR1 (Cleaved-Ser42) Polyclonal
      • Specificity:
      • This antibody detects endogenous levels of PAR1 (Cleaved-Ser42).
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000, ELISA 1:10000-20000
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
      • Observed Band(KD):
      • 46kD
      • Background:
      • Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
      • Function:
      • function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,
      • Subcellular Location:
      • Cell membrane; Multi-pass membrane protein.
      • Expression:
      • Platelets and vascular endothelial cells.
      • Products Images
      • Western blot analysis of MCF-7 lysate, antibody was diluted at 1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000