Stat6 Polyclonal Antibody

    • Catalog No.:YT4454
    • Applications:WB,IHC-p,ELISA
    • Reactivity:Human,Mouse,Rat,Monkey
      • Gene Name:
      • STAT6
      • Protein Name:
      • Signal transducer and activator of transcription 6
      • Human Gene Id:
      • 6778
      • Human Swiss Prot No:
      • P42226
      • Mouse Swiss Prot No:
      • P52633
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human STAT6. AA range:608-657
      • Specificity:
      • Stat6 Polyclonal Antibody detects endogenous levels of Stat6 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
      • MolecularWeight(Da):
      • 94135
      • Observed Band(KD):
      • 94
      • Background:
      • signal transducer and activator of transcription 6(STAT6) Homo sapiens The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
      • Function:
      • function:Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.,PTM:Tyrosine phosphorylated following stimulation by IL-4 and IL-3.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.,
      • Subcellular Location:
      • nuclear chromatin,nucleus,nucleoplasm,cytoplasm,cytosol,membrane raft,
      • Expression:
      • Uterus,
      • Products Images
      • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using STAT6 Antibody. The picture on the right is blocked with the synthesized peptide.
      • Western blot analysis of lysates from HeLa cells, using STAT6 Antibody. The lane on the right is blocked with the synthesized peptide.