Placental alkaline phosphatase (PLAP) mouse mAb

    • Catalog No.:YM1349
    • Applications:WB
    • Reactivity:Human
      • Target:
      • PLAP
      • Fields:
      • >>Thiamine metabolism;>>Folate biosynthesis;>>Metabolic pathways;>>Biosynthesis of cofactors
      • Gene Name:
      • alpp
      • Human Gene Id:
      • 250
      • Human Swiss Prot No:
      • P05187
      • Immunogen:
      • Purified recombinant Placental alkaline phosphatase (PLAP) protein fragments expressed in E.coli.
      • Specificity:
      • This antibody detects endogenous levels of Placental alkaline phosphatase (PLAP) and does not cross-react with related proteins.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Monoclonal, Mouse
      • Dilution:
      • wb 1:1000
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Alkaline phosphatase;Alkaline phosphatase placental;Alkaline phosphatase placental type;Alkaline phosphatase Regan isozyme;ALP;Alp1;ALPP;FLJ61142;Germ-cell alkaline phosphatase;nagao isozyme;OTTHUMP00000164354;PALP;Placental alkaline phosphatase 1;placental heat-stable alkaline phosphatase;placental type;PLAP;PLAP-1;PLAP1;PPB1_HUMAN.
      • Observed Band(KD):
      • 70kD
      • Background:
      • The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015],
      • Function:
      • catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,polymorphism:Placental ALP is highly polymorphic, there are at least three common alleles.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer.,
      • Subcellular Location:
      • Cell membrane; Lipid-anchor, GPI-anchor .
      • Expression:
      • Detected in placenta (at protein level).
      • Products Images
      • Western blot analysis of extracts from HepG2, Hela, CHO-K1 and CHO-K1 transfected pcDNA3.1-HA-PLAP cell lysates using Placental alkaline phosphatase (PLAP) mouse mAb (1:1000 diluted).Predicted band size:70KDa.Observed band size:70KDa.