Total Ksr2 Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3796C
- Applications:ELISA
- Reactivity:Human;Mouse
- Gene Name:
- KSR2
- Human Gene Id:
- 283455
- Human Swiss Prot No:
- Q6VAB6
- Mouse Swiss Prot No:
- Q3UVC0
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- Kinase suppressor of Ras 2 (hKSR2)
- Detection Method:
- Colorimetric
- Background:
- domain:The protein kinase domain is predicted to be catalytically inactive.,function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.,PTM:Phosphorylated on Ser-474 by MARK3.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF.,tissue specificity:Mainly expressed in brain and kidney.,
- Function:
- protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, phosphorylation,
- Subcellular Location:
- Cytoplasm . Membrane ; Peripheral membrane protein .
- Expression:
- Mainly expressed in brain and kidney.
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