Total AAK1 Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3776C
- Applications:ELISA
- Reactivity:Human;Mouse;Rat
- Gene Name:
- AAK1
- Human Gene Id:
- 22848
- Human Swiss Prot No:
- Q2M2I8
- Mouse Swiss Prot No:
- Q3UHJ0
- Rat Swiss Prot No:
- P0C1X8
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)
- Detection Method:
- Colorimetric
- Background:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Stimulated by clathrin.,function:Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Active when found in clathrin-coated pits at the plasma membrane.,subunit:Interacts with alpha-adaptin and AP-2.,
- Function:
- protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,
- Subcellular Location:
- Cell membrane ; Peripheral membrane protein . Membrane, clathrin-coated pit . Cell junction, synapse, presynapse . Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells. .
- Expression:
- Detected in brain, heart and liver. Isoform 1 is the predominant isoform in brain.
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