Total N/H/K-Ras Cell-Based Colorimetric ELISA Kit_ImmunoWay Biotechnology Company |抗体|病理抗体|诊断抗体

Total N/H/K-Ras Cell-Based Colorimetric ELISA Kit

Background：
disease:Defects in NRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia.,disease:Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.,enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).,function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.,online information:NRAS mutation db,online information:RAS proteins entry,PTM:Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.,similarity:Belongs to the small GTPase superfamily. Ras family.,subcellular location:Shuttles between the plasma membrane and the Golgi apparatus.,

Function：
endocytosis, apoptosis, cytoskeleton organization, intracellular signaling cascade, small GTPase mediated signal transduction, Ras protein signal transduction, aging, cell aging, behavior, learning or memory, learning, visual behavior, cell death, positive regulation of cell proliferation, visual learning, response to radiation, response to light stimulus, response to abiotic stimulus, positive regulation of signal transduction, membrane invagination, positive regulation of cell communication, regulation of cell death, programmed cell death, membrane organization, vesicle-mediated transport, death, actin filament-based process, actin cytoskeleton organization, regulation of neurological system process, regulation of synaptic transmission, GABAergic, regulation of Rac protein signal transduction, positive regulation of Rac protein signal transduction, regulation of cell proliferation, mus

Subcellular Location：
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus membrane ; Lipid-anchor . Shuttles between the plasma membrane and the Golgi apparatus. .