Total MMP-8 Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3334C
- Applications:ELISA
- Reactivity:Human;Mouse;Rat
- Gene Name:
- MMP8
- Human Gene Id:
- 4317
- Human Swiss Prot No:
- P22894
- Mouse Swiss Prot No:
- O70138
- Rat Swiss Prot No:
- O88766
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)
- Detection Method:
- Colorimetric
- Background:
- catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Cannot be activated without removal of the activation peptide.,function:Can degrade fibrillar type I, II, and III collagens.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Stored in intracellular granules.,tissue specificity:Neutrophils.,
- Function:
- skeletal system development, ossification, proteolysis, collagen catabolic process, collagen metabolic process,multicellular organismal metabolic process, multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process, bone development,
- Subcellular Location:
- Cytoplasmic granule. Secreted, extracellular space, extracellular matrix . Stored in intracellular granules.
- Expression:
- Neutrophils.
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