Total Melan-A Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3317C
- Applications:ELISA
- Reactivity:Human
- Gene Name:
- MLANA
- Human Gene Id:
- 2315
- Human Swiss Prot No:
- Q16655
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- Melanoma antigen recognized by T-cells 1 (MART-1) (Antigen LB39-AA) (Antigen SK29-AA) (Protein Melan-A)
- Detection Method:
- Colorimetric
- Background:
- tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
- Subcellular Location:
- Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
- Expression:
- Expression is restricted to melanoma and melanocyte cell lines and retina.
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