Total Fli-1 Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3263C
- Applications:ELISA
- Reactivity:Human;Mouse
- Gene Name:
- FLI1
- Human Gene Id:
- 2313
- Human Swiss Prot No:
- Q01543
- Mouse Swiss Prot No:
- P26323
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB)
- Detection Method:
- Colorimetric
- Background:
- disease:A chromosomal aberration involving FLI1 is a cause of Ewing sarcoma [MIM:133450]. Translocation t(11;22)(q24;q12) with EWS.,function:Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.,miscellaneous:Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Can form homodimers or heterodimers with ETV6/TEL1.,
- Function:
- circulatory system process, transcription, regulation of transcription, DNA-dependent, hemostasis, blood circulation,regulation of transcription, regulation of body fluid levels, regulation of RNA metabolic process,
- Subcellular Location:
- Nucleus .
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