Phospho Abl (Y412) Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA1777C
  • Applications：ELISA
  • Reactivity：Human;Mouse
    • Gene Name：
    • ABL1
    • Human Gene Id：
    • 27
    • Human Swiss Prot No：
    • P42684
    • Mouse Swiss Prot No：
    • Q4JIM5
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Abelson tyrosine-protein kinase 2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium or manganese.,enzyme regulation:Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the amino-terminal cap, and contributions from an amino-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML).,function:Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Widely expressed.,
    • Function：
    • protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cytoskeleton organization, actin filament organization, cell adhesion, phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, biological adhesion, actin filament-based process, actin cytoskeleton organization, positive regulation of catalytic activity, positive regulation of molecular function, actin filament bundle formation, regulation of oxidoreductase activity, positive regulation of oxidoreductase activity,
    • Subcellular Location：
    • Cytoplasm, cytoskeleton.
    • Expression：
    • Widely expressed.

    Attributes

    • Code：
    • KA1777C
    • Size
    • 96 / well
    • Price$：
    • 470
    • Delivery：
    • 2024-08-03
    Order

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