Total ILK Cell-Based Colorimetric ELISA Kit
- 货号：KA4138C
- 应用：ELISA
- 种属：Human;Mouse;Rat
- 其他名称：
- Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (ILK-1) (ILK-2) (p59ILK)
- 背景：
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:A PH-like domain is involved in phosphatidylinositol phosphate binding.,enzyme regulation:Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK.,function:Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.,PTM:Autophosphorylated on serine residues.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 ANK repeats.,subunit:Interacts with cytoplasmic domain of beta 1 subunit of integrin. Could also interacts with beta 2, beta 3 and/or beta 5 subunit of integrin. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with parvins and probably TGFB1I1.,tissue specificity:Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.,
- 功能：
- cell morphogenesis, cell morphogenesis involved in differentiation, regulation of action potential, regulation of cell growth, urogenital system development, metanephros development, ureteric bud development, branching involved in ureteric bud morphogenesis, morphogenesis of a branching structure, kidney development, regulation of cell-matrix adhesion, positive regulation of cell-matrix adhesion, morphogenesis of an epithelium, protein complex assembly,protein amino acid phosphorylation, negative regulation of protein kinase activity, phosphorus metabolic process,phosphate metabolic process, cellular ion homeostasis, cell cycle, cell cycle arrest, cell adhesion, cell-matrix adhesion,establishment or maintenance of cell polarity, cell surface receptor linked signal transduction, integrin-mediated signaling pathway, ensheathment of neurons, aging, cell aging, cell proliferation, positive r
- 细胞定位：
- Cell junction, focal adhesion . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cell projection, lamellipodium . Cytoplasm, myofibril, sarcomere .
- 组织表达：
- Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
