• Target：
• RBQ-3

• Fields：
• >>Cushing syndrome

• Gene Name：
• RBBP5

• Protein Name：
• Retinoblastoma-binding protein 5

• Human Gene Id：
• 5929

• Human Swiss Prot No：
• Q15291

• Mouse Gene Id：
• 213464

• Mouse Swiss Prot No：
• Q8BX09

• Immunogen：
• Synthesized peptide derived from RBQ-3 . at AA range: 190-270

• Specificity：
• RBQ-3 Polyclonal Antibody detects endogenous levels of RBQ-3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RBBP5;RBQ3;Retinoblastoma-binding protein 5;RBBP-5;Retinoblastoma-binding protein RBQ-3

• Observed Band(KD)：
• 59kD

• Background：
• This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010],

• Function：
• function:Binds preferentially to underphosphorylated retinoblastoma protein.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 6 WD repeats.,subunit:Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1.,tissue specificity:Ubiquitously expressed.,

• Subcellular Location：
• Nucleus .

• Expression：
• Ubiquitously expressed.

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