• Target：
• RBP4

• Gene Name：
• RBP4

• Protein Name：
• Retinol-binding protein 4

• Human Gene Id：
• 5950

• Human Swiss Prot No：
• P02753

• Mouse Swiss Prot No：
• Q00724

• Immunogen：
• Purified recombinant fragment of human RBP4 expressed in E. Coli.

• Specificity：
• RBP4 Monoclonal Antibody detects endogenous levels of RBP4 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RBP4;Retinol-binding protein 4;Plasma retinol-binding protein;PRBP;RBP

• Molecular Weight(Da)：
• 23kD

• References：
• 1. Diabetologia. 2008 Aug;51(8):1423-8.
  2. J Clin Endocrinol Metab. 2008 Aug;93(8):3142-8.

• Background：
• retinol binding protein 4(RBP4) Homo sapiens This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008],

• Function：
• disease:A deficiency of vitamin A blocks secretion of the binding protein post-translationally and results in defective delivery and supply of vitamin to the epidermal cells (a condition associated with a dermatosis).,disease:Defects in RBP4 are a cause of retinol-binding protein deficiency [MIM:180250]. This condition causes night vision problems. It produces a typical "fundus xerophthalmicus," featuring a progressed atrophy of the retinal pigment epithelium.,function:Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.,mass spectrometry: PubMed:12237133,mass spectrometry: PubMed:7666002,online information:Retina International's Scientific Newsletter,online information:Retinol-binding protein 4 entry,similarity:Belongs to the calycin superfamil

• Subcellular Location：
• Secreted .

• Expression：
• Detected in blood plasma and in urine (at protein level).

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