• Target：
• PI3 Kinase p85 β

• Fields：
• >>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>Platinum drug resistance;>>ErbB signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>HIF-1 signaling pathway;>>FoxO signaling pathway;>>Phosphatidylinositol signaling system;>>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Apoptosis;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Cellular senescence;>>Axon guidance;>>VEGF signaling pathway;>>Osteoclast differentiation;>>Focal adhesion;>>Signaling pathways regulating pluripotency of stem cells;>>Platelet activation;>>Neutrophil extracellular trap formation;>>Toll-like receptor signaling pathway;>>C-type lectin receptor signaling pathway;>>JAK-STAT signaling pathway;>>Natural killer cell mediated cytotoxicity;>>T cell receptor signaling pathway;>

• Gene Name：
• PIK3R2

• Protein Name：
• Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kD

• Human Gene Id：
• 5296

• Human Swiss Prot No：
• O00459

• Mouse Gene Id：
• 18709

• Mouse Swiss Prot No：
• O08908

• Immunogen：
• Synthetic peptide from human protein at AA range: 1-60

• Specificity：
• The antibody detects endogenous PI 3-Kinase p85β

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• p85;p85 beta;p85-BETA;P85B;P85B_HUMAN;Phosphatidylinositol 3 kinase;Phosphatidylinositol 3 kinase regulatory beta subunit;Phosphatidylinositol 3 kinase regulatory subunit beta;Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2;Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta);Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta;phosphatidylinositol 3-kinase;Phosphatidylinositol 3-kinase regulatory beta subunit;Phosphatidylinositol 3-kinase regulatory subunit beta;Phosphoinositide 3 kinase regulatory subunit 2 (beta);Phosphoinositide 3 kinase regulatory subunit 2;Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta);Phosphoinositide 3 kinase regulatory subunit polypeptide 2;Phosphoinositide 3 kinase, regulatory subunit 2 (beta);Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta);PI3 kinase p85 beta subunit;PI3 kinase p85 subunit beta;PI3-kinase regulatory subunit beta;PI3-kinase subunit p85-beta;PI3K;PI3K regulatory su

• Molecular Weight(Da)：
• 82kD

• Background：
• Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012],

• Function：
• function:Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.,similarity:Belongs to the PI3K p85 subunit family.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits.,

• Subcellular Location：
• nucleus,cytosol,phosphatidylinositol 3-kinase complex,

• Expression：
• Brain,Epithelium,Kidney,Placenta,

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Nanocarrier of Pin1 inhibitor based on supercritical fluid technology inhibits cancer metastasis by blocking multiple signaling pathways Regenerative Biomaterials Dayun Yang WB Human,Mouse lung tissues HuH7 cell,HepG2 cell

Taraxasterol Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis via the PI3K/Akt Signaling Pathway Natural Product Communications Wenwen Jang WB Human HepG2 cell, SMMC-7721 cell

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