• Target：
• TOB1

• Fields：
• >>RNA degradation

• Gene Name：
• TOB1

• Protein Name：
• Protein Tob1

• Human Gene Id：
• 10140

• Human Swiss Prot No：
• P50616

• Mouse Swiss Prot No：
• Q61471

• Rat Swiss Prot No：
• Q8R5K6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TOB1. AA range:130-179

• Specificity：
• TOB1 Polyclonal Antibody detects endogenous levels of TOB1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TOB1;TOB;TROB1;Protein Tob1;Transducer of erbB-2 1

• Observed Band(KD)：
• 40kD

• Background：
• This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

• Function：
• function:Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors.,PTM:Phosphorylated on Ser and Thr residues.,similarity:Belongs to the BTG family.,subunit:Interacts with CNOT7.,tissue specificity:Ubiquitous.,

• Subcellular Location：
• Cytoplasm . Nucleus . Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. .

• Expression：
• Ubiquitous.

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