PFKFB2 (Phospho Ser466) Rabbit pAb

  • Catalog No.:YP1872
  • Applications:IHC-p,WB
  • Reactivity:Human, Mouse,Rat
    • Fields:
    • >>Fructose and mannose metabolism;>>Metabolic pathways;>>AMPK signaling pathway;>>Thyroid hormone signaling pathway
    • Gene Name:
    • PFKFB2
    • Protein Name:
    • 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-
    • Sequence:
    • O60825
    • Human Gene Id:
    • 5208
    • Human Swiss Prot No:
    • O60825
    • Mouse Swiss Prot No:
    • P70265
    • Immunogen:
    • Synthesized peptide derived from human PFKFB2 (Phospho Ser466)
    • Specificity:
    • This antibody detects endogenous levels of PFKFB2 (Phospho Ser466) Rabbit pAb at Human, Mouse,Rat
    • Formulation:
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source:
    • Rabbit,polyclonal
    • Dilution:
    • WB 1:500-2000 IHC 1:50-200
    • Purification:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
    • Observed Band(KD):
    • 58kD
    • Background:
    • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2(PFKFB2) Homo sapiens The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
    • Function:
    • catalytic activity:ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.,catalytic activity:Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.,enzyme regulation:Phosphorylation results in the activation of the kinase activity.,function:Synthesis and degradation of fructose 2,6-bisphosphate.,similarity:In the C-terminal section; belongs to the phosphoglycerate mutase family.,subunit:Homodimer.,tissue specificity:Heart.,
    • Expression:
    • Heart.