• Target：
• SOX-2

• Fields：
• >>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells

• Gene Name：
• SOX2

• Protein Name：
• Transcription factor SOX-2

• Human Gene Id：
• 6657

• Human Swiss Prot No：
• P48431

• Mouse Gene Id：
• 20674

• Mouse Swiss Prot No：
• P48432

• Immunogen：
• Recombinant protein

• Specificity：
• This antibody detects endogenous levels of SOX-2 protein.

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Mouse, Monoclonal/IgG1,kappa

• Dilution：
• WB 1:500-2000.IF 1:100-500.ELISA 1:1000-5000.

• Purification：
• Protein G

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SOX2;Transcription factor SOX-2

• Molecular Weight(Da)：
• 34kD

• Observed Band(KD)：
• 34kD

• Background：
• SRY-box 2(SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.,function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,online information:Sox2 entry,PTM:Sumoylation inhibits bin

• Subcellular Location：
• Nuclear

• Expression：
• Fetal brain,Lung,Retina,

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