• Target：
• CD19

• Gene Name：
• CD19

• Protein Name：
• B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)

• Human Gene Id：
• 930

• Human Swiss Prot No：
• P15391

• Immunogen：
• Purified recombinant Human CD19

• Specificity：
• This recombinant monoclonal antibody can detects endogenous levels of CD19 protein.

• Formulation：
• Phosphate-buffered solution

• Source：
• Monoclonal,Mouse,IgG1,kappa

• Dilution：
• ELISA 1:5000-100000;FCM 1-2μg/Test

• Purification：
• Recombinant Expression and Affinity purified

• Concentration：
• Please check the information on the tube

• Storage Stability：
• -15°C to -25°C/1 year(Avoid freeze / thaw cycles)

• Other Name：
• B-lymphocyte antigen CD19;Cd19;Differentiation antigen CD19;CD19;Antibody deficiency due to defect in CD19 antibody;Antibody deficiency due to defect in CD19;included antibody;AW495831 antibody;B lymphocyte antigen CD19 antibody;B lymphocyte surface antigen B4 antibody;B-lymphocyte antigen CD19 antibody;B-lymphocyte surface antigen B4 antibody;B4 antibody;CD19 antibody;CD19 antigen antibody;CD19 molecule antibody;Cd19 protein antibody;CD19_HUMAN antibody;CVID3 antibody;Differentiation antigen CD19 antibody;Leu 12 antibody;Leu-12 antibody;Leu12 antibody;MGC109570 antibody;MGC12802 antibody;T-cell surface antigen Leu-12 antibody;

• Background：
• CD19 molecule(CD19) Homo sapiens Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors.This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

• Function：
• Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores . Is not required for early steps during B cell differentiation in the blood marrow . Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge .

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .

• Expression：
• Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:24631). Detected on blood B cells (at protein level) (PubMed:24631, PubMed:1667271).

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