• Target：
• Trk C

• Fields：
• >>Calcium signaling pathway;>>Neurotrophin signaling pathway;>>Central carbon metabolism in cancer

• Gene Name：
• NTRK3

• Protein Name：
• NT-3 growth factor receptor

• Human Gene Id：
• 4916

• Human Swiss Prot No：
• Q16288

• Mouse Swiss Prot No：
• Q6VNS1

• Immunogen：
• Purified recombinant extracellular fragment of human Trk C (aa32-429) fused with hIgGFc tag expressed in HEK293 cells.

• Specificity：
• Trk C Monoclonal Antibody detects endogenous levels of Trk C protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• NTRK3;TRKC;NT-3 growth factor receptor;GP145-TrkC;Trk-C;Neurotrophic tyrosine kinase receptor type 3;TrkC tyrosine kinase

• Molecular Weight(Da)：
• 94kD

• References：
• 1. BMC Cancer. 2007 Oct 31;7:202.
  2. J Pathol. 2002 Aug;197(5):661-7.

• Background：
• This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],

• Function：
• alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.,PTM:Ligand-mediated auto-phosphorylation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 2 LRR (leucine-rich) repeats.,subunit:Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220.,tissue specificity:Widely expressed but mainly i

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

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