Trk A Monoclonal Antibody

    • Catalog No.：YM0628
    • Applications：WB;IF;ELISA
    • Reactivity：Human
      • Target：
      • Trk A
      • Fields：
      • >>MAPK signaling pathway;>>Ras signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Apoptosis;>>Neurotrophin signaling pathway;>>Inflammatory mediator regulation of TRP channels;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Thyroid cancer;>>Central carbon metabolism in cancer
      • Gene Name：
      • NTRK1
      • Protein Name：
      • High affinity nerve growth factor receptor
      • Human Gene Id：
      • 4914
      • Human Swiss Prot No：
      • P04629
      • Mouse Swiss Prot No：
      • Q3UFB7
      • Immunogen：
      • Purified recombinant extracellular fragment of human Trk A (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
      • Specificity：
      • Trk A Monoclonal Antibody detects endogenous levels of Trk A protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • NTRK1;MTC;TRK;TRKA;High affinity nerve growth factor receptor;Neurotrophic tyrosine kinase receptor type 1;TRK1-transforming tyrosine kinase protein;Tropomyosin-related kinase A;Tyrosine kinase receptor;Tyrosine kinase receptor A;
      • Molecular Weight(Da)：
      • 87kD
      • References：
      • 1. DNA Repair (Amst). 2008 Oct 1;7(10):1757-64.
        2. Traffic. 2008 Jul;9(7):1146-56.
      • Background：
      • This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008],
      • Function：
      • alternative products:Both isoforms have similar biological properties,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Chromosomal aberrations involving NTRK1 are a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Intrachromosomal rearrangement that links the protein kinase domain of NTRK1 to the 5'-end of the TPR gene forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the C-terminus of the NTRK1 protein.,disease:Chromosomal aberrations involving NTRK1 are a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(1;3)(q21;q11) with TFG generates the TRKT3 (TRK-T3) transcript by fusing TFG to the 3'-end of NTRK1; a rearrangement with TPM3 gen
      • Subcellular Location：
      • Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Recycling endosome membrane ; Single-pass type I membrane protein . Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. .
      • Expression：
      • Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
      • Products Images
      • Western Blot analysis using Trk A Monoclonal Antibody against extracellular domain of human Trk A (aa33-423).
      • Confocal immunofluorescence analysis of PC-12 cells using Trk A Monoclonal Antibody (green), showing membrane and cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye.

      Attributes

      • Code：
      • YM0628
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-11-29
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