CD62L (PN0038) Nb-FC recombinant antibody

    • Catalog No.:YA0423
    • Applications:ELISA;FCM
    • Reactivity:Human
      • Target:
      • CD62L
      • Gene Name:
      • SELL LNHR LYAM1
      • Protein Name:
      • L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing re
      • Human Gene Id:
      • 6402
      • Human Swiss Prot No:
      • P14151
      • Immunogen:
      • Purified recombinant Human CD62L
      • Specificity:
      • This recombinant monoclonal antibody can detects endogenous levels of CD62L protein.
      • Formulation:
      • Phosphate-buffered solution
      • Source:
      • Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
      • Dilution:
      • ELISA 1:5000-100000 FCM 1-2μg/Test
      • Purification:
      • Recombinant Expression and Affinity purified
      • Concentration:
      • Please check the information on the tube
      • Storage Stability:
      • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
      • Other Name:
      • TQ1;LAM1;LEU8;LNHR;LSEL;CD62L;LYAM1;PLNHR;LECAM1;L-selectin;LECAM-1;SELL;LAM-1;TQ-1;MEL-14;CD62L nanobody;
      • Background:
      • CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naïve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells.
      • Function:
      • Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
      • Subcellular Location:
      • Cell membrane ; Single-pass type I membrane protein .
      • Expression:
      • Expressed in B-cell lines and T-lymphocytes.
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