• Target：
• CD62L

• Gene Name：
• SELL LNHR LYAM1

• Protein Name：
• L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing re

• Human Gene Id：
• 6402

• Human Swiss Prot No：
• P14151

• Immunogen：
• Purified recombinant Human CD62L

• Specificity：
• This recombinant monoclonal antibody can detects endogenous levels of CD62L protein.

• Formulation：
• Phosphate-buffered solution

• Source：
• Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell

• Dilution：
• ELISA 1:5000-100000 FCM 1-2μg/Test

• Purification：
• Recombinant Expression and Affinity purified

• Concentration：
• Please check the information on the tube

• Storage Stability：
• -15°C to -25°C/1 year(Avoid freeze / thaw cycles)

• Other Name：
• TQ1;LAM1;LEU8;LNHR;LSEL;CD62L;LYAM1;PLNHR;LECAM1;L-selectin;LECAM-1;SELL;LAM-1;TQ-1;MEL-14;CD62L nanobody;

• Background：
• CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naïve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells.

• Function：
• Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Expressed in B-cell lines and T-lymphocytes.

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