CD62L (PN0037) Nb-FC recombinant antibody

  • Catalog No.:YA0422
  • Applications:ELISA;FCM
  • Reactivity:Human
    • Target:
    • CD62L
    • Gene Name:
    • SELL LNHR LYAM1
    • Protein Name:
    • L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing re
    • Human Gene Id:
    • 6402
    • Human Swiss Prot No:
    • P14151
    • Immunogen:
    • Purified recombinant Human CD62L
    • Specificity:
    • This recombinant monoclonal antibody can detects endogenous levels of CD62L protein.
    • Formulation:
    • Phosphate-buffered solution
    • Source:
    • Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
    • Dilution:
    • ELISA 1:5000-100000 FCM 1-2μg/Test
    • Purification:
    • Recombinant Expression and Affinity purified
    • Concentration:
    • Please check the information on the tube
    • Storage Stability:
    • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
    • Other Name:
    • TQ1;LAM1;LEU8;LNHR;LSEL;CD62L;LYAM1;PLNHR;LECAM1;L-selectin;LECAM-1;SELL;LAM-1;TQ-1;MEL-14;CD62L nanobody;
    • Background:
    • CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naïve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells.
    • Function:
    • Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
    • Subcellular Location:
    • Cell membrane ; Single-pass type I membrane protein .
    • Expression:
    • Expressed in B-cell lines and T-lymphocytes.