CD4 (PN0615) Nb-FC recombinant antibody

  • Catalog No.：YA0349
  • Applications：ELISA
  • Reactivity：Human
    • Target：
    • CD4
    • Gene Name：
    • CD4
    • Protein Name：
    • T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
    • Human Gene Id：
    • 920
    • Human Swiss Prot No：
    • P01730
    • Immunogen：
    • Purified recombinant Human CD4
    • Specificity：
    • This recombinant monoclonal antibody can detects endogenous levels of CD4 protein.
    • Formulation：
    • Phosphate-buffered solution
    • Source：
    • Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
    • Dilution：
    • ELISA 1:5000-100000
    • Purification：
    • Recombinant Expression and Affinity purified
    • Concentration：
    • Please check the information on the tube
    • Storage Stability：
    • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
    • Other Name：
    • T-cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;CD antigen CD4;CD4 nanobody;
    • Background：
    • This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus.This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified inThis gene. [provided by RefSeq, Aug 2010]
    • Function：
    • Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cyt
    • Subcellular Location：
    • Cell membrane ; Single-pass type I membrane protein . Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
    • Expression：
    • Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.

    Attributes

    • Code：
    • YA0349
    • Size
    • 40μg / 100μg / 200μg
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-09-22
    Order

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