CD155 (PN0424) Nb-FC recombinant antibody

  • Catalog No.：YA0113
  • Applications：ELISA
  • Reactivity：Human
    • Target：
    • CD155
    • Gene Name：
    • PVR PVS
    • Protein Name：
    • Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)
    • Human Gene Id：
    • 5817
    • Human Swiss Prot No：
    • P15151
    • Immunogen：
    • Purified recombinant Human CD155
    • Specificity：
    • This recombinant monoclonal antibody can detects endogenous levels of CD155 protein.
    • Formulation：
    • Phosphate-buffered solution
    • Source：
    • Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
    • Dilution：
    • ELISA 1:5000-100000
    • Purification：
    • Recombinant Expression and Affinity purified
    • Concentration：
    • Please check the information on the tube
    • Storage Stability：
    • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
    • Other Name：
    • PVR;PVS;Poliovirus receptor;Nectin-like protein 5;NECL-5;CD155
    • Background：
    • The protein encoded by This gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found forThis gene. [provided by RefSeq, Oct 2008]
    • Function：
    • Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the micr
    • Subcellular Location：
    • [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cell membrane; Single-pass type I membrane protein.; [Isoform Beta]: Secreted.; [Isoform Gamma]: Secreted.
    • Expression：
    • Liver,Pancreas,Placenta,Plasma

    Attributes

    • Code：
    • YA0113
    • Size
    • 40μg / 100μg / 200μg
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-11-25
    Order

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