CD14 (PN0642) Nb-FC recombinant antibody

  • Catalog No.：YA0087
  • Applications：ELISA
  • Reactivity：Human
    • Target：
    • CD14
    • Gene Name：
    • CD14
    • Protein Name：
    • Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation a
    • Human Gene Id：
    • 929
    • Human Swiss Prot No：
    • P08571
    • Immunogen：
    • Purified recombinant Human CD14
    • Specificity：
    • This recombinant monoclonal antibody can detects endogenous levels of CD14 protein.
    • Formulation：
    • Phosphate-buffered solution
    • Source：
    • Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
    • Dilution：
    • ELISA 1:5000-100000
    • Purification：
    • Recombinant Expression and Affinity purified
    • Concentration：
    • Please check the information on the tube
    • Storage Stability：
    • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
    • Other Name：
    • Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein;CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14;urinary form;Monocyte differentiation antigen CD14;membrane-bound form]
    • Background：
    • The protein encoded byThis gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
    • Function：
    • Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.,online information:CD14 entry,similarity:Contains 11 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.,
    • Subcellular Location：
    • Cell membrane ; Lipid-anchor, GPI-anchor . Secreted . Membrane raft . Golgi apparatus . Secreted forms may arise by cleavage of the GPI anchor. .
    • Expression：
    • Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

    Attributes

    • Code：
    • YA0087
    • Size
    • 40μg / 100μg / 200μg
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-11-26
    Order

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