• Target：
• CD131

• Gene Name：
• CSF2RB IL3RB IL5RB

• Protein Name：
• Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)

• Human Gene Id：
• 1439

• Human Swiss Prot No：
• P32927

• Immunogen：
• Purified recombinant Human CD131

• Specificity：
• This recombinant monoclonal antibody can detects endogenous levels of CD131 protein.

• Formulation：
• Phosphate-buffered solution

• Source：
• Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell

• Dilution：
• ELISA 1:5000-100000

• Purification：
• Recombinant Expression and Affinity purified

• Concentration：
• Please check the information on the tube

• Storage Stability：
• -15°C to -25°C/1 year(Avoid freeze / thaw cycles)

• Other Name：
• IL-3R common β chain;CDw131;Beta-C antibody;CD131 antibody;CDw131 antibody;Colony stimulating factor 2 receptor beta antibody;Colony stimulating factor 2 receptor beta low affinity (granulocyte macrophage) antibody;Common beta chain antibody;Csf2rb antibody;Cytokine receptor common beta chain antibody;Cytokine receptor common beta chain precursor (CDw131 antigen) antibody;Cytokine receptor common subunit beta antibody;GM CSF/IL 3/IL 5 receptor common beta chain antibody;GM-CSF/IL-3/IL-5 receptor common beta subunit antibody;granulocyte-macrophage colony-stimulating factor receptor;beta antibody;IL3RB antibody;IL3RB_HUMAN antibody;IL5RB antibody;Interleukin 3 receptor;beta antibody;Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta (high affinity) antibody;Interleukin 5 receptor;beta antibody;SMDP5 antibody;stimulating factor 3 receptor;beta (high affinity) antibody;

• Background：
• CD131, also known as the IL-3R common β subunit , is a 95-120 kD type I transmembrane glycoprotein and belongs to the Ig superfamily. The common β subunit associates with the specific α subunits of IL-3 receptor, IL-5 receptor and GM-CSF receptor to form high affinity receptors for these cytokines. These cytokine receptors are expressed by neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts and hematopoietic progenitor cells and play a crucial role in growth/activation of eosinophils and in the inflammatory response. The 1C1 antibody is a non-blocking antibody.

• Function：
• Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124).

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

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