Total XRCC1 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA4327C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • XRCC1
    • Human Gene Id：
    • 7515
    • Human Swiss Prot No：
    • P18887
    • Mouse Swiss Prot No：
    • Q60596
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)
    • Detection Method：
    • Colorimetric
    • Background：
    • function:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.,
    • Function：
    • single strand break repair, response to hypoxia, DNA metabolic process, DNA repair, response to DNA damage stimulus, response to organic substance, cellular response to stress, response to drug, response to oxygen levels,
    • Subcellular Location：
    • Nucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. .
    • Expression：
    • Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).

    Attributes

    • Code：
    • KA4327C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-12-07
    Order

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