Total XIAP Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA4326C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • XIAP
    • Human Gene Id：
    • 331
    • Human Swiss Prot No：
    • P98170
    • Mouse Swiss Prot No：
    • Q60989
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
    • Detection Method：
    • Colorimetric
    • Background：
    • disease:Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2) [MIM:300635]. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.,domain:The first BIR domain is involved in interaction with MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated by the second and third BIR domains.,function:Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B.,online information:XIAP mutation db,PTM:Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against proteasomal degradation.,PTM:Ubiquitinated and degraded by the proteasome in apoptotic cells.,similarity:Belongs to the IAP family.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Monomer, and homodimer. Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with MAP3K7IP1 and AIFM1. Interaction with SMAC hinders binding of MAP3K7IP1 and AIFM1. Interacts with TCF25.,tissue specificity:Ubiquitous, except peripheral blood leukocytes.,
    • Function：
    • proteolysis, apoptosis, anti-apoptosis, response to DNA damage stimulus, cell death, macromolecule catabolic process, regulation of cell death, programmed cell death, death, modification-dependent protein catabolic process,protein catabolic process, cellular response to stress, regulation of apoptosis, negative regulation of apoptosis,regulation of programmed cell death, negative regulation of programmed cell death, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process,proteolysis involved in cellular protein catabolic process, negative regulation of cell death,
    • Subcellular Location：
    • Cytoplasm. Nucleus. TLE3 promotes its nuclear localization.
    • Expression：
    • Expressed in colonic crypts (at protein level) (PubMed:30389919). Ubiquitous, except peripheral blood leukocytes (PubMed:8654366).

    Attributes

    • Code：
    • KA4326C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-05-09
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