• Gene Name：
• WWOX

• Human Gene Id：
• 51741

• Human Swiss Prot No：
• Q9NZC7

• Mouse Swiss Prot No：
• Q91WL8

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase)

• Detection Method：
• Colorimetric

• Function：
• skeletal system development, ossification, osteoblast differentiation, induction of apoptosis, steroid metabolic process, negative regulation of signal transduction, negative regulation of cell communication, regulation of cell death,positive regulation of cell death, induction of programmed cell death, regulation of Wnt receptor signaling pathway,negative regulation of Wnt receptor signaling pathway, regulation of apoptosis, positive regulation of apoptosis,regulation of programmed cell death, positive regulation of programmed cell death, skeletal system morphogenesis,oxidation reduction, bone development,

• Subcellular Location：
• Cytoplasm . Nucleus . Mitochondrion . Golgi apparatus . Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus. .

• Expression：
• Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

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