Total VAV3 Cell-Based Colorimetric ELISA Kit_ImmunoWay Biotechnology Company |抗体|病理抗体|诊断抗体

Total VAV3 Cell-Based Colorimetric ELISA Kit

Background：
function:Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with the PH domain of APS.,

Function：
vesicle fusion, apoptosis, induction of apoptosis, cell motion, membrane fusion, cell surface receptor linked signal transduction, integrin-mediated signaling pathway, intracellular signaling cascade, small GTPase mediated signal transduction, cell death, induction of apoptosis by extracellular signals, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, membrane organization, vesicle organization,vesicle-mediated transport, death, cell migration, regulation of lipid metabolic process, regulation of phosphate metabolic process, cell projection organization, cell projection assembly, lamellipodium assembly, regulation of cell adhesion, positive regulation of kinase activity, regulation of Rho protein signal transduction, regulation of phosphorylation, regulation of apoptosis, positive regulation of apoptosis, regulation o

Expression：
Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.