Total MSK2 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA4188C
  • Applications：ELISA
  • Reactivity：Human;Mouse
    • Gene Name：
    • RPS6KA4
    • Human Gene Id：
    • 8986
    • Human Swiss Prot No：
    • O75676
    • Mouse Swiss Prot No：
    • Q9Z2B9
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Appears to be activated by multiple phosphorylations on threonine and serine residues. ERK1/2 and p38 kinases may play a role in this process.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. Essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF) and result in the transcriptional activation of several immediate early genes, including proto-oncogenes FOS and JUN (By similarity). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).,miscellaneous:Enzyme activity requires the presence of both kinase domains.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA4 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.,
    • Function：
    • regulation of transcription, DNA-dependent, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, intracellular signaling cascade, protein kinase cascade, phosphorylation, regulation of transcription, regulation of RNA metabolic process,
    • Subcellular Location：
    • Nucleus .

    Attributes

    • Code：
    • KA4188C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-07-31
    Order

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