Total Collagen IV α2 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA4046C
  • Applications：ELISA
  • Reactivity：Human;Mouse
    • Gene Name：
    • COL4A2
    • Human Gene Id：
    • 1284
    • Human Swiss Prot No：
    • P08572
    • Mouse Swiss Prot No：
    • P08122
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Collagen alpha-2(IV) chain [Cleaved into: Canstatin]
    • Detection Method：
    • Colorimetric
    • Background：
    • domain:Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.,function:Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,PTM:The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.,PTM:Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.,similarity:Belongs to the type IV collagen family.,similarity:Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.,subunit:There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.,
    • Function：
    • negative regulation of angiogenesis, extracellular matrix organization, extracellular structure organization, regulation of angiogenesis,
    • Subcellular Location：
    • Secreted, extracellular space, extracellular matrix, basement membrane.

    Attributes

    • Code：
    • KA4046C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-08-01
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