Cleaved-MMP-12 (G106) Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3966C
  • Applications：ELISA
  • Reactivity：Human
    • Gene Name：
    • MMP12
    • Human Gene Id：
    • 4321
    • Human Swiss Prot No：
    • P39900
    • Mouse Swiss Prot No：
    • P34960
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.,induction:By exposure to lipopolysaccharide. Inhibited by dexamethasone.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Found in alveolar macrophages but not in peripheral blood monocytes.,
    • Function：
    • proteolysis, positive regulation of cell proliferation, regulation of cell proliferation, response to drug, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation,
    • Subcellular Location：
    • Secreted, extracellular space, extracellular matrix .
    • Expression：
    • Found in alveolar macrophages but not in peripheral blood monocytes.

    Attributes

    • Code：
    • KA3966C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-05-03
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