Cleaved-Factor XIIIa (G39) Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3948C
  • Applications：ELISA
  • Reactivity：Human
    • Gene Name：
    • F13A1
    • Human Gene Id：
    • 2162
    • Human Swiss Prot No：
    • P00488
    • Mouse Swiss Prot No：
    • Q8BH61
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).,cofactor:Binds 1 calcium ion per subunit.,disease:Defects in F13A1 are the cause of F13A deficiency [MIM:134570]. F13A deficiency is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. In addition to the common presentation such as subcutaneous and intramuscular haematomas, severe bleeding such as intracranial hemorrhages may occur.,function:Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.,online information:Factor XIII entry,online information:The Singapore human mutation and polymorphism database,polymorphism:There are four main allelic forms of this protein; F13A*1A, F13A*1B, F13A*2A and F13A*2B. In addition two other intermediate forms (F13A*(2)A and F13A*(2)B) seem to exist. The sequence shown is that of F13A*(2)B.,PTM:The activation peptide is released by thrombin.,similarity:Belongs to the transglutaminase superfamily. Transglutaminase family.,subcellular location:Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.,subunit:Tetramer of two A chains and two B chains.,
    • Function：
    • blood coagulation, hemostasis, response to wounding, peptide cross-linking, wound healing, coagulation, regulation of body fluid levels,
    • Subcellular Location：
    • Cytoplasm. Secreted . Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.

    Attributes

    • Code：
    • KA3948C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-05-04
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