• Gene Name：
• DLC1

• Human Gene Id：
• 10395

• Human Swiss Prot No：
• Q96QB1

• Mouse Swiss Prot No：
• Q9R0Z9

• Rat Swiss Prot No：
• Q63744

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12)

• Detection Method：
• Colorimetric

• Background：
• function:Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization.,sequence caution:Chimera. Sequence from position 1 to 13 is due to a chimera.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 1 START domain.,tissue specificity:Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.,

• Function：
• embryonic epithelial tube formation, neural tube formation, neural tube closure, morphogenesis of an epithelium,heart morphogenesis, apoptosis, induction of apoptosis, activation of caspase activity, cytoskeleton organization, cell-substrate junction assembly, cell adhesion, cell-matrix adhesion, heart development, cell death, negative regulation of cell proliferation, regulation of cell shape, embryonic development ending in birth or egg hatching, negative regulation of signal transduction, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, negative regulation of organelle organization, negative regulation of cell communication, regulation of cell death, positive regulation of cell death, positive regulation of peptidase activity, programmed cell death,induction of programmed cell death, primary neural tube formation, death, morp

• Subcellular Location：
• Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Colocalizes with EF1A1 at actin-rich regions in the cell periphery.

• Expression：
• Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.

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