Total MAST205 Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3794C
- Applications:ELISA
- Reactivity:Human;Mouse
- Gene Name:
- MAST2
- Human Gene Id:
- 23139
- Human Swiss Prot No:
- Q6P0Q8
- Mouse Swiss Prot No:
- Q60592
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)
- Detection Method:
- Colorimetric
- Background:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation.,PTM:Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Recruited to the sub-membranous area on interaction with PC-LKC.,tissue specificity:Abundant in the testis.,
- Function:
- regulation of cytokine production, reproductive developmental process, protein amino acid phosphorylation,phosphorus metabolic process, phosphate metabolic process, gamete generation, spermatogenesis, phosphorylation,sexual reproduction, multicellular organism reproduction, regulation of interleukin-12 production, regulation of cytokine biosynthetic process, regulation of interleukin-12 biosynthetic process, male gamete generation, spermatid differentiation, reproductive process in a multicellular organism, reproductive cellular process,
- Subcellular Location:
- Cytoplasm, cytoskeleton . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Recruited to the sub-membranous area on interaction with CDHR2.
- Expression:
- Abundant in the testis.
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