Total 3pK Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3767C
- Applications:ELISA
- Reactivity:Human;Mouse;Rat
- Gene Name:
- MAPKAPK3
- Human Gene Id:
- 7867
- Human Swiss Prot No:
- Q16644
- Mouse Swiss Prot No:
- Q3UMW7
- Rat Swiss Prot No:
- Q66H84
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)
- Detection Method:
- Colorimetric
- Background:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK. Substrate of CSBP. In vitro, phosphorylates HSPB1, BMI1/PCGF4 and TCF3.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Predominantly located in the nucleus, when activated it translocates to the cytoplasm.,subunit:Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.,tissue specificity:Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain.,
- Function:
- protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, small GTPase mediated signal transduction, Ras protein signal transduction, phosphorylation,
- Subcellular Location:
- Nucleus . Cytoplasm . Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
- Expression:
- Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. Expressed in the retinal pigment epithelium (PubMed:26744326).
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