Total Rho H Cell-Based Colorimetric ELISA Kit_ImmunoWay Biotechnology Company |抗体|病理抗体|诊断抗体

Total Rho H Cell-Based Colorimetric ELISA Kit

Other Name：
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)

Background：
disease:A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocation t(3;4)(q27;p11) with BCL6.,similarity:Belongs to the small GTPase superfamily. Rho family.,tissue specificity:Transcribed only in hemopoietic cells.,

Function：
cell activation, immune system development, leukocyte differentiation, intracellular signaling cascade, small GTPase mediated signal transduction, negative regulation of signal transduction, regulation of protein kinase cascade,negative regulation of cell communication, negative regulation of protein kinase cascade, hemopoiesis, lymphocyte differentiation, T cell differentiation, T cell activation, regulation of I-kappaB kinase/NF-kappaB cascade, negative regulation of I-kappaB kinase/NF-kappaB cascade, leukocyte activation, regulation of transcription, lymphocyte activation, hemopoietic or lymphoid organ development,

Subcellular Location：
Cytoplasm . Cell membrane ; Lipid-anchor ; Cytoplasmic side . Colocalizes together with ZAP70 in the immunological synapse. .

Expression：
Expressed only in hematopoietic cells. Present at very high levels in the thymus, less abundant in the spleen, and least abundant in the bone marrow. Expressed at a higher level in the TH1 subtype of T-helper cells than in the TH2 subpopulation. Expressed in neutrophils under inflammatory conditions, such as cystic fibrosis, ulcerative colitis and appendicitis.