Total p57 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3621C
  • Applications：ELISA
  • Reactivity：Human
    • Gene Name：
    • CDKN1C
    • Human Gene Id：
    • 1028
    • Human Swiss Prot No：
    • P49918
    • Mouse Swiss Prot No：
    • P49919
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
    • Detection Method：
    • Colorimetric
    • Background：
    • disease:Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.,disease:Defects in CDKN1C are involved in tumor formation.,function:Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.,
    • Function：
    • regulation of cyclin-dependent protein kinase activity, G1 phase of mitotic cell cycle, negative regulation of transcription from RNA polymerase II promoter, mitotic cell cycle, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, cell cycle, cell cycle arrest, negative regulation of cell proliferation, negative regulation of biosynthetic process, positive regulation of signal transduction, negative regulation of macromolecule biosynthetic process, negative regulation of phosphorus metabolic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, positive regulation of cell communication, negative regulation of transcription, regulation of transforming growth factor beta receptor signaling pathway, regulation of phosphate metabolic process, developmental maturation, cell cycle process, cel
    • Subcellular Location：
    • Nucleus .
    • Expression：
    • Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

    Attributes

    • Code：
    • KA3621C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-08-02
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