Total Casein Kinase Iε Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3617C
  • Applications：ELISA
  • Reactivity：Human;Mouse
    • Gene Name：
    • CSNK1E
    • Human Swiss Prot No：
    • P49674
    • Mouse Swiss Prot No：
    • Q9JMK2
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation.,induction:Down-regulated during granulocytic differentiation.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with ANKRD6 and SOCS3.,tissue specificity:Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.,
    • Function：
    • DNA metabolic process, DNA repair, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, response to DNA damage stimulus, phosphorylation, cellular response to stress,
    • Subcellular Location：
    • Cytoplasm . Nucleus .
    • Expression：
    • Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.

    Attributes

    • Code：
    • KA3617C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-08-02
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