Total ALK-1 Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3599C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • ACVRL1
    • Human Gene Id：
    • 94
    • Human Swiss Prot No：
    • P37023
    • Mouse Swiss Prot No：
    • Q61288
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 GS domain.,similarity:Contains 1 protein kinase domain.,
    • Function：
    • angiogenesis, regulation of cell growth, blood vessel development, in utero embryonic development, vasculature development, regulation of cell-matrix adhesion, negative regulation of cell-matrix adhesion, circulatory system process, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell motion, negative regulation of cell adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, blood circulation, regulation of blood pressure, negative regulation of cell proliferation, regulation of cell size, response to wounding, embryonic development ending in birth or egg hatching, positive regulation of biosynthetic process, positive regulation of signal transduction, posi
    • Subcellular Location：
    • Cell membrane ; Single-pass type I membrane protein .

    Attributes

    • Code：
    • KA3599C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-08-02
    Order

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