Total PKAα/β cat Cell-Based Colorimetric ELISA Kit_ImmunoWay Biotechnology Company |抗体|病理抗体|诊断抗体

Total PKAα/β cat Cell-Based Colorimetric ELISA Kit

Function：
formation of primary germ layer, mesoderm formation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, protein kinase cascade, gastrulation,mesoderm development, response to endogenous stimulus, response to hormone stimulus, hormone-mediated signaling, response to organic substance, phosphorylation, peptidyl-serine phosphorylation, peptidyl-serine modification, regulation of phosphate metabolic process, regulation of neurological system process, activation of protein kinase activity, regulation of intracellular transport, positive regulation of intracellular transport, cellular response to hormone stimulus, regulation of protein localization, regulation of intracellular protein transport, positive regulation of kinase activity, activation of protein kinase A activity, regulation of phosphorylation, positive reg

Subcellular Location：
Cytoplasm. Cell membrane. Nucleus . Mitochondrion . Membrane ; Lipid-anchor . Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). Colocalizes with HSF1 in nuclear stress bodies (nSBs) upon heat shock (PubMed:21085490). .; [Isoform 2]: Cell projection, cilium, flagellum . Cytoplasmic vesicle, secretory vesicle, acrosome . Expressed in the midpiece region of the sperm flagellum (PubMed:10906071). Colocalizes with MROH2B and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardle

Expression：
Isoform 1 is ubiquitous. Isoform 2 is sperm-specific and is enriched in pachytene spermatocytes but is not detected in round spermatids.